Mesquite Bay is the northern most bay in the Coastal Bend region. It is home to the much loved Cedar Bayou. Cedar Bayou is a natural pass between St. Joseph's and Matagorda Island that has periodically been opened and closed by hurricanes through out history. .
Surrounded by tidal lakes and marshes, Mesquite Bay is well know for its redfish, trout and flounder populations. Bordered by the Aransas Wildlife Refuge to the west and uninhabited St. Joseph and Matagorda Islands to the south and east, access to Mesquite Bay is limited, keeping fishing pressure down, compared to other area bays.
Navigating Mesquite Bay can be hazardous because of the large number of unmarked oyster reefs spread thought the bay and extreme caution should be exercised. Most boaters enter the bay on the northwest end from the Intracoastal Waterway.